William Harveys Discoveries and Effects on Society

William Harveys Discoveries and Effects on Society The Renaissance, which means rebirth, was a time of much literary and humanistic growth dating from 1350-1600 AD. During this period, scholars and intellectuals alike began to show interest and respect for the arts, literature, science and architecture again. The humanistic growth of this time refers to the scholars of the renaissance, known as Humanists, who put themselves and humankind at the centre of their world and culture rather than God. The Renaissance originated in northern Italy but eventually took over Europe, with clergymen and bishops moving to Italy to study   what was known as the New Learning. The invention of the printing press during this time also meant that books could be mass produced, quickly and cheaply for the first time, making them more widely available to humanists and those in the public that could afford such commodities. This led to increased learning in this time, which in turn led to great scientists and scholars being born who changed the way we loo k at the world, even today. (colaisteeanna.ie, 2011) William Harvey, alongside Galileo, Kepler and Bacon was a very important individual in the advancement of science in the renaissance period, who is credited today as being one of the most influential English physicians in history. He is mostly known for his research into the circulatory system and was the first person to discover and accurately describe how blood was transported throughout the body by the heart. Harvey was known for never fearing to go beyond what science had accepted in his time and for pushing the boundaries of Renaissance science, never having any fear to experiment on things that would be considered major taboos at the time. His exploits however would lead to the public and other physicians to write off his work completely. William was born in Folkstone, Kent, England in the year 1578 to Thomas and mother of nine, Joane Harvey. Williams father, Thomas, was quite a successful merchant who would go on to become the mayor of his town which meant that William lived a quite comfortable life growing up. As a child and young teen Harvey was taught the classics and latin, which would later aide him in his ventures to Europe where Latin was widely used for academic work. In 1597, Harvey attended Gonville and Caius College in the University of Cambridge where he studied and completed a bachelors degree. Upon completing his degree, Harvey thought it best to move on to study medicine in the highly prestigious University of Padua in northern Italy. At the time Italy was known to be one of the great centres of intellectual activity in Europe. It was in Padua that Harvey would go on to study and be tutored under the great and famous surgeon and scientist Hieronymus Fabricius. Fabricius was a dedicated anatomist who wa s revolutionising medicine in the renaissance period who had discovered that veins in the human body contained valves, although to use of these valves were unknown to him. His beliefs in the workings of scientists such as Galen were so strong that he didnt want to challenge these views which meant that Fabricius would never go on to further his studies in this area. Fabricius discovery would later inspire Harvey to further these studies. Harvey would then go on to receive the degree of M.D from the University of Padua in 1602, where on his diploma it was written [Harvey] had conducted himself so wonderfully well in the examination, and had shown such skill, memory and learning that he had far surpassed even the great hopes which his examiners had formed of him. They decided therefore that he was skilful, expert, and most efficiently qualified both in arts and medicineâ‚ ¬Ã‚ ¦ (Famousscientists.org, 2015). He would then go on to return to England to join and perform well in his ex ams at the Royal College of Physicians. During the renaissance period, the scientist and anatomist, Galen, was widely renowned as the greatest physician to ever have lived. Galen believed that the body was made up of bodily fluids called humors, these included blood, yellow bile, black bile and phlegm. Galens views were unanimously agreed upon and people of the time saw these humors in the same way that DNA and genes are viewed in modern science today. For example if somebody was optimistic or positive it would suggest, in Galens teachings, that the humor, blood, was the primary bodily fluid to make up said persons body. The same would be applied for someone who was bad tempered who would be thought to be mostly made up of yellow bile. Although these findings were widely accepted, Galen was never able to prove them outright as at the time, dissecting human bodies was forbidden and was widely believed that it would lead to the dissector not going to heaven upon death. It was these accepted views that would lead future scien tists, such as Fabricius, to not want to challenge Galen or conduct any sort of experiments that would be considered taboo at the time. (World Science Festival, 2014). Although Harvey was very curious and would go on to investigate Fabricius studies further as he was not a believer of this ideology, which meant that he wasnt afraid to conduct experiments such as dissecting and other procedures that would have been considered unthinkable at the time. His practices though, did not come without his critics, who believed in the workings of medieval scientist and anatomist Galen. It would be Harveys eventual rise through the ranks of the college of physicians and his marriage to Elizabeth Browne, daughter of the physician to the queen at the time Elizabeth the First, however, that would give Harvey the time and space needed to conduct his controversial experiments. His marriage into a family of power and his expertise as a fellow physician to his new father in law would lead to him becoming the physician extraordinary to Queen Elizabeths successor, King James the first. Harvey would begin through human dissection to open up arteries and begin to study blood flow and blood like nobody had ever before him. Harveys work was based on a range of experiments and observations, including applying ligatures to arms to compare the flow of blood through arteries and veins and to establish the role of valves and some live experimentation on the hearts and vessels of fish and snakes. (Underhill, 2015)   Harvey also used mathematical data to prove that the blood was not being consumed (Ribatti, 2009). Harvey continued to experiment until he was able to provide concrete evidence to publish for the public to view. In 1628, at the age of 50, Harvey published his findings in latin under the title: Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibusor in English as On the Motion of the Heart and Blood. It provided new evidence on blood circulation for the first time since Galen, who had believed that blood was produced in the liver from food and pumped to the lungs. It has been shown by reason and experiment that blood by the beat of the ventricles flows through the lungs and heart and is pumped to the whole body. There it passes through pores in the flesh into the veins through which it returns from the periphery everywhere to the centre, from the smaller veins into the larger ones, finally coming to the vena cava and right atrium. (Ribatti, 2009) Harveys findings went completely against the works of Galen   which sparked outrage in the scientific community as Galens work was regarded as untouchable at the time. The medical community grew hostile against Harvey and began to send hi m threats and insults. Always a believer of his work though, Harvey would never stop trying to defend his findings. Unfortunately this abuse did not end and his practice began to suffer because of it. Eventually it forced Harvey into isolation where he lived out his life as a recluse to avoid any unnecessary attention on himself. This wasnt the end for Harvey however as a new generation of budding medical students were on the rise, who were ready to disregard old teachings and pursue modern medical studys which Harvey pioneered with his research. Harvey would continue to give lectures to the new generation of scientists, detailing his methods and findings and who would then go on to use these findings and methods in their own research which would eventually make the works of Harvey mainstream, eventually making him into a more influential scientist than Galen, whose work is still used today. His sceptics outrage ended in 1661, four years after Harveys death, when scientist Marcello Malpighi discovered capillaries which finally gave factual evidence and proved Harveys theory of blood circulation. William Harveys discoveries and their eventual acceptance meant that medical practises in general improved greatly during the end of the renaissance period and beyond. His discoveries in the circulatory system and his students further studies into his field allowed for new, more complex operations to take place. This had a big effect on heart surgeons as before Harvey, nobody really knew much about the functions of the heart. This allowed for a greater, although still very low survival rate for cardiac patients as new experimental operative methods were used through trial and error. The next 100 years would prove vital for advancements in cardiac related research as followers and accepters of Harveys work would lead major breakthroughs that have lead up to where modern heart and circulatory surgery is today. To conclude, William Harvey was a very influential scientist who lived in a time and culture where people outright believed the views of medieval medicine. A time where the medical community was unwilling to challenge the views of the greats such as Galen. Harvey showed the scientific community that no matter what your views or stance on a particular science is, that if you keep an open mind you may just be proven wrong in the end. William Harvey was the landmark scientist of modern medicine who paved the way for what we consider modern medicine to be today. Harvey was the inspiration for a whole generation of anatomists and physicians in his time and for future centuries to come. Who to this day is used as the benchmark for how influential a physician can be. Thanks to Harveys willingness to abandon old wisdom and observe and test for himself, we have our modern understanding of physiology. (www.discoveriesinmedicine.com , 2006) References: Harvey, william first, blood, body, Harveys contribution, Harvey publishes his findings (2006) Available at: http://www.discoveriesinmedicine.com/General-Information-and-Biographies/Harvey-William.html. Ribatti, D. (2009). William Harvey and the discovery of the circulation of the blood. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776239/ Underhill, S. (2015) 6.2 circulation Galen and Harvey. Available at: https://natureofscienceib.wordpress.com/2015/11/18/6-2-circulation-galen-and-harvey/ World Science Festival (2014) Misunderstood geniuses: William Harvey. Available at: https://www.youtube.com/watch?v=7NOU4McjtXs colaisteeanna.ie. (2011). The Renaissance. [online] Available at: http://colaisteeanna.ie/wp-content/uploads/2011/01/History-Revision-The-Renaissance.pdf Famousscientists.org. (2015). William Harvey Biography, Facts and Pictures. [online] Available at: https://www.famousscientists.org/william-harvey/

Properties of Enzymes and Competitive Inhibitors

Index Page Abstract†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. †¦. †¦Ã¢â‚¬ ¦. 3 Introduction†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. †¦. †¦Ã¢â‚¬ ¦.. 3 Materials and Chemicals used†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. †¦Ã¢â‚¬ ¦. †¦.. 3 Procedures†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. †¦Ã¢â‚¬ ¦ †¦Ã¢â‚¬ ¦ †¦Ã¢â‚¬ ¦ 4 Tables†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â ‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 5-7 Results†¦Ã¢â‚¬ ¦.. †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ †¦Ã¢â‚¬ ¦8 Discussion†¦. †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ †¦Ã¢â‚¬ ¦8 Conclusion†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. †¦Ã¢â‚¬ ¦. 8 Works Cited †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 9 Properties of Enzymes and Competitive Inhibitors. Abstract: Properties of enzymes were found in this experiment and some other factors, which affect enzyme activity.Enzymes are catalyst; they catalyze very specific reactions. Results relating to the active site of specific enzymes played a big role while performing this experiment. The purpose of this experiment was to fin how inhibitors affect enzyme’s activity by competing for the active site against substrates. Introduction: Cells have the ability to perform chemical reactions that at normal temperature outside the body proceed too slowly to support life. Cells are able to perform some reactions rapidly because they possess protein catalyst called enzymes. Enzymes are proteins that catalyze (i. . , increase the rates of) chemical reactions. Each enzyme has a unique globular shape, a small portion of which functions as an active site capable of binding to specific reactants or substrates. It was hypothesized that enzyme concentration, temperature, and inhibitors will affect the properties and abilities of the enzyme. Materials: 1Wax Marking Pens 150 ml Beakers 3 400 ml Beaker 1 container of parafilm 1 set of 20 spec tubes 1 regular test tube rack 1 small test tube rack 1 box Kimwipes Eye Droppers 1 thermometer 2-10ml Graduated Cylinders 1 Spectrophotometer 7  °C waterbath with test tube racks Solutions: 1 flasks of pH 7 buffered ONPG 1 flask of Lactose 8% 1 flask of pH 7 buffered 1 flasks of 8% beta galactosidase Procedure 1. Obtain five test tubes and label them (i. e. A, B, C, D, E) 2. Using a 10 ml graduated cylinder put: Note: It is very important to add enzyme last. 1 ml of pH 7 buffered ONPG + No Lactose 8%(0ml) +(1 ml pH buffer) + Enzyme (1ml) solutions into tube A. 0% Lactose. 3. Using a 10 ml graduated cylinder put: 1 ml of pH 7 buffered ONPG + Lactose 8% (. 25ml) +(. 75ml pH buffer) + Enzyme (1ml) so lutions into tube B. % Lactose. 4. Using a 10 ml graduated cylinder put: 1 ml of pH 7 buffered ONPG + Lactose 8% (. 5ml) +(. 5ml pH buffer) + Enzyme (1ml) solutions into tube C. 4% Lactose. 5. Using a 10 ml graduated cylinder put: 1 ml of pH 7 buffered ONPG + Lactose 8% (. 75ml) +(. 25ml pH buffer) + Enzyme (1ml) solutions into tube D. 6% Lactose. 6. Using a 10 ml graduated cylinder put: 1 ml of pH 7 buffered ONPG + Lactose 8% (1ml) +(0ml pH buffer) + Enzyme (1ml) solutions into tube E. 8% Lactose. 7. Cover each of the tubes with parafilm and place the tubes in the 37  °C waterbath for 30 minutes. . After 30 minutes, determine if the reaction has occurred in each tube, and notice change in color. 9. Test tube E acted as our control test tube because no competitive inhibitor was added. Lactose was the competitive inhibitor for this reaction into the test tube. Note: Because the result on steps 4 and 6 were not accurate for our particular experiment, steps 4 and 6 were performed twi ce. The following table and graph express the results after the measurements and mixing. Table 1. Measurements after mixing the solutions into the test tubes.Solutions| pH 7 Buffered ONPG (ml)| Lactose 8% (ml)| pH buffer (ml)| Enzyme B-Gal (ml)| Total amount of mls. | Test tube A| 1| 0| 1| 1| 3| Test tube B| 1| 0. 25| 0. 75| 1| 3| Test tube C| 1| 0. 5| 0. 5| 1| 3| Test tube D| 1| 0. 75| 0. 25| 1| 3| Test tube E| 1| 1| 0| 1| 3| This table represents the total amounts of each solution added to each test tube in order to get 3 mls for each test tube. This table is used only to represent how the result will look like. Graph 1. Measurements after mixing the solutions into the test tubes. This graph depicts the contents inside the test tubes after mixing the mentioned solutions.Measurement of O-nitrophenol. (ONPG) Although the appearance of yellow in the tubes indicated that O-nitrophenol was present, the color, alone, did not tell us how much was present. It was possible to measure the a mount of O-nitrophenol present by measuring the intensity of the yellow with a spectrophotometer. 1. The contents of the 5 tubes were poured into spec 20 tubes. The positions were labeled, but the spec tubes were left clear in order to have an accurate measurement absorbance. 2. Test tube E acted as the control tube for this, since that tube did not contain inhibitor.Note: Absorbance 420nm in this experiment will be a measure of the concentration of the O-nitrophenol molecules in each of the solutions. Using the Spectrophotometer The spectrophotometer was an instrument designed to measure the amount of light transmitted through solutions, or absorbed by substances in the solution. Light of a specific wavelength is emitted from a special bulb and passed through a tube containing a substance solution. The greater concentration of those particles; the greater the absorbance. It is very important to select the most appropriate wavelength of light for use.These procedures were followed i n order to set up the Spectrophotometer. 1. 420 nm was the wavelength to use in the inhibitor experiment lab designed because O-nitrophenol maximally absorbs a light at 420. 2. The Spectrophotometer was zeroed out with the control knob so that the needle reads 0% transmittance on the upper scale. 3. The control tube A was put in the holder, and the lid was closed. The light control knob was adjusted so that the needle could read 100% transmittance. 4. The control tube was removed from the holder. The lid was then closed noticing the needle again read 0% transmittance. 5.All other test tubes were placed into the Spectrophotometer and read as well. 6. Data for these results was recorded on the following table. Table 2. Effect of competitive inhibitor concentration lactose on the production of O-nitrophenol. Effect of Competitive Inhibitor Concentration on production of ONGP Product| Tube| Inhibitor Concentration| Intensity of yellow| Absorbance| ? moles of ONPG produced/30min | ? mole s of ONPG produced/min| A| 0%| ++++| 1. 55| 38. 75| 1. 291666667| B| 2%| +++| 0. 43| 107. 5| 3. 583333333| C| 4%| ++| 0. 13| 32. 5| 1. 083333333| D| 6%| +| 0. 02| 5| 0. 166666667| E| 8%| 0 | 0| 0| 0|Calculation of ? moles O-nitrophenol produced per minutes. Ex. Tube A: ? moles of ONPG produced/30min Absorbance/0. 004= ? moles of ONPG produced per 30min 0. 155 / 0. 004= 38. 75 ? moles Ex 2 Tube A: ? moles of ONPG produced/min ?moles of ONPG produced per 30min/ 30min 38. 75 /30=1. 291666667 ? moles of ONPG produced/min From the absorbance data that was measured the O-nitrophenol produced per minute was calculated. 1. Each ? mole of O-nitrophenol produced an absorbance of 0. 004. The absorbance measured was divided by 0. 004 to determine the number of ? moles produced during the experiment.The values were recorded in table 2, fifth column. 2. The measurements that were obtained in the fifth column were divided by 30(number of minutes left in the waterbath) to obtain the number of ? mol es of O-nitrophenol produced per minute. Graph 2. Absorbance measurements for inhibitor concentration lactose on the production of O-nitrophenol. Absorbance Absorbance Test Tubes Test Tubes Results According to the hypothesis that temperature, enzyme concentration, and concentration will affect the properties and functions of the enzymes. The hypothesis was supported because graph and tables express the change in absorbance, and ? oles produced. Discussion The tables were able to depict the result in order to get better and accurate results for this particular experiment. Measurements have to be performed with precaution, making sure the enzyme and the contents are mixed properly and at the same time. Conclusion Enzyme activity can be affected by other molecules. Inhibitors are molecules that decrease enzyme activity; activators are molecules that increase activity. Activity is also affected by temperature, chemical environment, change in pH, and the concentration of substrate.

Language And Cognitive Development Based On A Longitudinal...

The following is a review of the article â€Å"New Evidence About Language and Cognitive Development Based on a Longitudinal Study: Hypotheses for Intervention† (Goldin-Meadow et al., 2014). The article discusses the research that was done on language learning in toddlers. I will summarize the purpose of the research, the methods used, and an interpretation of the findings. I will then discuss the findings in relation to developmental theories as discussed by Berger (2014). I will conclude with a reflection on how this relates to my own experience. Purpose of the Research The authors undertook this research in order to better understand the factors that affect language learning. The findings obtained through this research may help predict†¦show more content†¦The researches did 90-minute home observations every four months for four years (total of 12 visits per child). The children were observed from the age of 14 months to 58 months. The researches also observed 40 children with unilateral brain injury (BI). There was no demographic related selection for these 40 children and they varied in age from 14 to 54 months. At least four visits were done with these 40 families. Parent-child interactions were videotaped for 90 minutes during each visit. All parent and child gestures and speech were then transcribed. Interpretation of Findings The authors discussed three outcomes in their research. The first is that SES and BI can cause variance in child gestures. The use of gestures can be an indicator of later language use in both typically developing children and children with brain injuries. In the group of typically developing children, it was found the use of gestures varies based on the SES. A difference in gesture use was found in children at 14 months of age, and that different in gesture use affected later language learning. The amount of parental gestures was related to SES and affected the amount of child gestures. Although parent gestures do not impact language learning, early child gestures do. Therefore, if the amount of parent gestures, impacts the amount of child gestures, language learning can be impacted as a result of fewer child gestures. The

An Analysis of Langston Hughes Poem Harlem - 1520 Words

Poems Harlem by Langston Hughes Thesis statement: Hughes wrote this when Jim Crow laws were still imposing an bitter segregated society in the South. There were still lynchings of innocent African Americans, there was no Civil Rights Movement, there was no Civil Rights legislation yet, and Blacks couldnt eat at lunch counters in the South. Harlem, however, was not at all like the South in terms of blatant, legal segregation. However, racism was very much in place in many places in America. Blacks were second class citizens, their children attended schools that were ill-equipped, and the dreams of Black citizens were not being realized in this period. The use of figurative language definitely adds to the poets message, in a big way. Hughes asks What happens to a dream deferred and in that line he uses alliteration. He doesnt say what the dream was, but the reader knows he is alluding to the dreams of Black Americans because the title Harlem represents a community in New York City that is heavily populated with Black folks. His use of similes is very effective when he compares the dream to a raisin (a simile is prefaced by like) Does it dry up like a raisin in the sun? Another use of alliteration is found in that line with does and dry (Hughes). The use of simile appears again with Or fester like a sore (a dream linked to a sore); And they run? (this is a metaphor because dreams dont run it also appears to be personification, making a dream intoShow MoreRelated Harlem, An Analysis of a Langston Hughes Poem Essay1405 Words   |  6 PagesHarlem, An Analysis of a Langston Hughes Poem The short but inspirational poem Harlem by Langston Hughes addresses what happens to aspirations that are postponed or lost. 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He wrote song lyrics, essays, autobiographies and plays however, his multi-dimensional style of writing consistedRead MoreReoccurring Themes in the Work of Langston Hughes Essay1649 Words   |  7 PagesLangston Hughes is an extremely successful and well known black writer who emerged from the Harlem Renaissance (â€Å"Langston Hughes† 792). He is recognized for his poetry and like many other writers from the Harlem Renaissance, lived most of his life outside of Harlem (â€Å"Langston Hughes† 792). His personal experiences and opinions inspire his writing intricately. Unlike other writers of his time, Hughes expresses his discontent with black oppression and focuses on the hardships of his people. Hughes’Read MoreLiterary Analysis of Langston Hughess A Dream Deferred1028 Words   |  4 Pagespublished, and circulated, analysis of the poem must take place. It unveils and discusses the themes, figures of speech, word placement, and flow of the piece, and A Dream Deferred, is no exception. In Langston Hughess poem, A Dream Deferred, the theme is that no really knows to dreams if they are not reached, and very realistic figures of speech help convey this idea; the poem can be surprisingly related to Mr. Hughess life through the subtitle and quotes from Langston himself. The meaning ofRead MoreLangston Hughes : A Modernist1222 Words   |  5 PagesSappington 13 Apr. 2017 Langston Hughes: A Modernist Credited as being the most recognizable figure of the Harlem Renaissance, Langston Hughes played a vital role in the Modernist literary movement and the movement to revitalize African American culture in the early 20th century. Hughes’s poems reflect his personal struggle and the collective struggle of African Americans during this cultural revival. Langston Hughes’s life contained key influences on his work. As a child, Hughes witnessed a divorceRead MoreAnalysis Of The Poem The Weary Blues Essay1299 Words   |  6 Pagesone of many Langston Hughes’s poetry during the Harlem Renaissance. The Harlem Renaissance is a time in American history, in the cities where African Americans were concentrated like Harlem, many master pieces of art, music and literature were created. Blues was much enjoyed during the period; people listened to it and loved it. In the poem of The Weary Blues, people alive through music, and the strong power of music supported the suffering of the black people in that time period. The poem describesRead MoreAnalysis Of Langston Hughes s Poem I, Too978 Words   |  4 Pages Langston Hughes America, the ideals of freedom, equality, and opportunity traditionally held to be available to every American. This is what everyone was told, what the Declaration of Independence states. But, Langston Hughes a black American poet in the Harlem Renaissance period saw the truth. Being an African American in the United States during the early 1900’s was difficult. Many lived a life full of hardships; segregation, prejudice and economic hardships, viewed as second-class citizensRead MoreLangston Hughes Theme For English B845 Words   |  4 PagesIn â€Å"Theme for English B† Langston Hughes dramatizes race and self-identity. Hughes is struggling to relate himself to his teacher and everyone around him, so he starts off by telling readers about his background such as his age and where he has lived. â€Å"I am twenty-two, colored, born in Winston- Salem† (2). Through the first stanza of the poem we know that Hughes is living through a time where race is a big issu e and not too many African American adolescents are in school like he is. He is learningRead MoreHarlem: a Dream Deferred1043 Words   |  5 PagesHarlem: A Dream Deferred Langston Hughes Literally Analysis Dreams are aspirations that we hope to reach on our lifetime. They are the day that gives us the drive to live our lives and accomplish our goals. When reaching our goals, we will do anything to get to our destination. But what happens when your dreams deferred and put on hold due to unseen circumstances? Or what do you so when someone tells you that you can not so the things you want to so because of the pigmentation of your skin